Since animal models do not develop advanced diabetic complications it is difficult to understand the mechanisms of progression of complications and to test new treatments. The need for such animal models would be somewhat mitigated if there was greater access to adequate amounts of human material (see Roadblock 2). For some microvascular complications, animal models are not representative and care needs to be exercised when trying to translate results from conditions in experimental models to conditions in man. The need to develop robust animal models is addressed in part in the research section (see Milestone 5.4.02).

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