No single centre can expect to conduct appropriate intervention trials for new therapies or assess whether abnormal tests in asymptomatic patients are predictive of the symptomatic manifestations. The rarity of some manifestations of microvascular complications means that sufficient numbers of people with the condition can only be accessed through a European-wide platform such as the EPCRD that would also facilitate the long-term studies essential to much of the research strategy outlined in this road map.

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