Biobanks containing tissue samples from a large number of well-documented patients with representative inclusion criteria could significantly hasten research and help to confirm that markers are associated with tissue damage. This could be achieved through the European Platform for Clinical Research in Diabetes (EPCRD) proposed in Chapter 4. Alternative systems are of only limited value. Cell culture is limited in exposure time and may thus only represent early, transient transcriptional changes. The use of cell lines often ignores specific cell propensities, and macrovascular endothelial cells are not representative of microvascular alterations.

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